Sarif Industries

Changes after returning from Highland Park:

Changes after returning after Picus:

Sarif Plant

Note: after dealing with Sanders all remaining enemies will be gone and everything can be explored safely.

Detroit City

Note: the state of the city, including locks/computers, vendor inventories, items and open side quests is still exactly the same after returning from Highland Park. There are also no new side quests.

Changes after returning from Montreal:

Highland Park

Hengsha

Changes on second visit:

Note: enemies in Harvester Hideout become friendly after reaching the first objective, so the place can safely be looted.

Tai Yong Medical

Picus

Ship

Rifleman Bank Station

Omega Ranch

Panchaea